Isolation of two members of the rat MAP kinase kinase gene family

Masayuki Otsu, Yasuhiko Terada, Hiroto Okayama

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Mitogen-activated protein (MAP) kinase kinase (MAPKK) is a recently characterized activator of MAP kinase (MAPK), and is considered to be regulated by a protooncogene product c-Raf-1. It is, however, unclear whether the signals originating from c-Raf-1 utilize this phosphorylation cascade to lead to oncogenesis. To clarify this point, we isolated rat MAPKK cDNAs, and identified two distinct cDNAs encoding MAPKK and a highly related kinase, both with molecular weights of 4̃5 kDa (MEK1 and MEK2). Genomic Southern blot analyses suggested that MAPKK. may form a large gene family.

本文言語English
ページ(範囲)246-250
ページ数5
ジャーナルFEBS Letters
320
3
DOI
出版ステータスPublished - 1993 4 12
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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