Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity

Yumi Hayashi, Wataru Fukasawa, Tomoyasu Hirose, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Masahiro Kanaida, Kenichi Nonaka, Akira Take, Kazuhiko Otoguro, Satoshi Omura, Kazuro Shiomi, Toshiaki Sunazuka

研究成果: Article

抄録

Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.

元の言語English
ジャーナルOrganic Letters
DOI
出版物ステータスPublished - 2019 1 1

Fingerprint

Antimalarials
Bioactivity
isolation
broths
synthesis
Lipopeptides
Chloroquine
Therapeutic Uses
Plasmodium falciparum

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

これを引用

Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species : Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. / Hayashi, Yumi; Fukasawa, Wataru; Hirose, Tomoyasu; Iwatsuki, Masato; Hokari, Rei; Ishiyama, Aki; Kanaida, Masahiro; Nonaka, Kenichi; Take, Akira; Otoguro, Kazuhiko; Omura, Satoshi; Shiomi, Kazuro; Sunazuka, Toshiaki.

：: Organic Letters, 01.01.2019.

研究成果: Article

Hayashi, Y, Fukasawa, W, Hirose, T, Iwatsuki, M, Hokari, R, Ishiyama, A, Kanaida, M, Nonaka, K, Take, A, Otoguro, K, Omura, S, Shiomi, K & Sunazuka, T 2019, 'Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity' Organic Letters. https://doi.org/10.1021/acs.orglett.9b00483
Hayashi Y, Fukasawa W, Hirose T, Iwatsuki M, Hokari R, Ishiyama A その他. Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. Organic Letters. 2019 1 1. https://doi.org/10.1021/acs.orglett.9b00483
Hayashi, Yumi ; Fukasawa, Wataru ; Hirose, Tomoyasu ; Iwatsuki, Masato ; Hokari, Rei ; Ishiyama, Aki ; Kanaida, Masahiro ; Nonaka, Kenichi ; Take, Akira ; Otoguro, Kazuhiko ; Omura, Satoshi ; Shiomi, Kazuro ; Sunazuka, Toshiaki. / Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species : Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. ：: Organic Letters. 2019.
@article{a9e695c531dd4d378c2246c497949498,
title = "Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity",
abstract = "Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.",
author = "Yumi Hayashi and Wataru Fukasawa and Tomoyasu Hirose and Masato Iwatsuki and Rei Hokari and Aki Ishiyama and Masahiro Kanaida and Kenichi Nonaka and Akira Take and Kazuhiko Otoguro and Satoshi Omura and Kazuro Shiomi and Toshiaki Sunazuka",
year = "2019",
month = "1",
day = "1",
doi = "10.1021/acs.orglett.9b00483",
language = "English",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",

}

TY - JOUR

T1 - Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species

T2 - Isolation, Structural Elucidation, Total Synthesis, and Bioactivity

AU - Hayashi, Yumi

AU - Fukasawa, Wataru

AU - Hirose, Tomoyasu

AU - Iwatsuki, Masato

AU - Hokari, Rei

AU - Ishiyama, Aki

AU - Kanaida, Masahiro

AU - Nonaka, Kenichi

AU - Take, Akira

AU - Otoguro, Kazuhiko

AU - Omura, Satoshi

AU - Shiomi, Kazuro

AU - Sunazuka, Toshiaki

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.

AB - Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.

UR - http://www.scopus.com/inward/record.url?scp=85063103411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063103411&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.9b00483

DO - 10.1021/acs.orglett.9b00483

M3 - Article

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

ER -

文献にアクセス