抄録
Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.
本文言語 | English |
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ジャーナル | Organic Letters |
DOI | |
出版ステータス | Published - 2019 1月 1 |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学