Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity

Yumi Hayashi; Wataru Fukasawa; Tomoyasu Hirose; Masato Iwatsuki; Rei Hokari; Aki Ishiyama; Masahiro Kanaida; Kenichi Nonaka; Akira Take; Kazuhiko Otoguro; Satoshi Omura; Kazuro Shiomi; Toshiaki Sunazuka

doi:10.1021/acs.orglett.9b00483

Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity

Yumi Hayashi, Wataru Fukasawa, Tomoyasu Hirose, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Masahiro Kanaida, Kenichi Nonaka, Akira Take, Kazuhiko Otoguro, Satoshi Omura, Kazuro Shiomi, Toshiaki Sunazuka

ナノ・ライフ創新研究機構

研究成果: Article

3 引用（Scopus）

抜粋

Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.

元の言語	English
ジャーナル	Organic Letters
DOI	https://doi.org/10.1021/acs.orglett.9b00483
出版物ステータス	Published - 2019 1 1

フィンガープリント

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

これを引用

Hayashi, Y., Fukasawa, W., Hirose, T., Iwatsuki, M., Hokari, R., Ishiyama, A., Kanaida, M., Nonaka, K., Take, A., Otoguro, K., Omura, S., Shiomi, K., & Sunazuka, T. (2019). Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. Organic Letters. https://doi.org/10.1021/acs.orglett.9b00483

Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species : Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. / Hayashi, Yumi; Fukasawa, Wataru; Hirose, Tomoyasu; Iwatsuki, Masato; Hokari, Rei; Ishiyama, Aki; Kanaida, Masahiro; Nonaka, Kenichi; Take, Akira; Otoguro, Kazuhiko; Omura, Satoshi; Shiomi, Kazuro; Sunazuka, Toshiaki.

：: Organic Letters, 01.01.2019.

研究成果: Article

Hayashi, Yumi ; Fukasawa, Wataru ; Hirose, Tomoyasu ; Iwatsuki, Masato ; Hokari, Rei ; Ishiyama, Aki ; Kanaida, Masahiro ; Nonaka, Kenichi ; Take, Akira ; Otoguro, Kazuhiko ; Omura, Satoshi ; Shiomi, Kazuro ; Sunazuka, Toshiaki. / Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species : Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. ：: Organic Letters. 2019.

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T2 - Isolation, Structural Elucidation, Total Synthesis, and Bioactivity

AU - Hayashi, Yumi

AU - Fukasawa, Wataru

AU - Hirose, Tomoyasu

AU - Iwatsuki, Masato

AU - Hokari, Rei

AU - Ishiyama, Aki

AU - Kanaida, Masahiro

AU - Nonaka, Kenichi

AU - Take, Akira

AU - Otoguro, Kazuhiko

AU - Omura, Satoshi

AU - Shiomi, Kazuro

AU - Sunazuka, Toshiaki

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文献にアクセス

10.1021/acs.orglett.9b00483