Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity

Yumi Hayashi; Wataru Fukasawa; Tomoyasu Hirose; Masato Iwatsuki; Rei Hokari; Aki Ishiyama; Masahiro Kanaida; Kenichi Nonaka; Akira Take; Kazuhiko Otoguro; Satoshi Omura; Kazuro Shiomi; Toshiaki Sunazuka

doi:10.1021/acs.orglett.9b00483

Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity

Yumi Hayashi, Wataru Fukasawa, Tomoyasu Hirose, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Masahiro Kanaida, Kenichi Nonaka, Akira Take, Kazuhiko Otoguro, Satoshi Omura, Kazuro Shiomi^*, Toshiaki Sunazuka

^*この研究の対応する著者

ナノ・ライフ創新研究機構

研究成果 › 査読

6 被引用数 (Scopus)

抄録

Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.

本文言語	English
ジャーナル	Organic Letters
DOI	https://doi.org/10.1021/acs.orglett.9b00483
出版ステータス	Published - 2019 1 1

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/acs.orglett.9b00483

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引用スタイル

Hayashi, Y., Fukasawa, W., Hirose, T., Iwatsuki, M., Hokari, R., Ishiyama, A., Kanaida, M., Nonaka, K., Take, A., Otoguro, K., Omura, S., Shiomi, K., & Sunazuka, T. (2019). Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. Organic Letters. https://doi.org/10.1021/acs.orglett.9b00483

Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species : Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. / Hayashi, Yumi; Fukasawa, Wataru; Hirose, Tomoyasu; Iwatsuki, Masato; Hokari, Rei; Ishiyama, Aki; Kanaida, Masahiro; Nonaka, Kenichi; Take, Akira; Otoguro, Kazuhiko; Omura, Satoshi; Shiomi, Kazuro; Sunazuka, Toshiaki.

In: Organic Letters, 01.01.2019.

研究成果 › 査読

Hayashi, Yumi ; Fukasawa, Wataru ; Hirose, Tomoyasu ; Iwatsuki, Masato ; Hokari, Rei ; Ishiyama, Aki ; Kanaida, Masahiro ; Nonaka, Kenichi ; Take, Akira ; Otoguro, Kazuhiko ; Omura, Satoshi ; Shiomi, Kazuro ; Sunazuka, Toshiaki. / Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species : Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. In: Organic Letters. 2019.

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