Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

Youichi Nakao, Wesley Y. Yoshida, Yuuki Takada, Junji Kimura, Liu Yang, Susan L. Mooberry, Paul J. Scheuer

研究成果: Article

54 引用 (Scopus)

抄録

A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

元の言語English
ページ(範囲)1332-1340
ページ数9
ジャーナルJournal of Natural Products
67
発行部数8
DOI
出版物ステータスPublished - 2004 8
外部発表Yes

Fingerprint

depsipeptides
Depsipeptides
chemical degradation
Mollusca
molluscs
inhibitory concentration 50
cytotoxicity
cell lines
Cells
Spectroscopic analysis
antineoplaston A10
Cytotoxicity
Inhibitory Concentration 50
Cell Line
Degradation
neoplasm cells
kulokekahilide-2
Neoplasms

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

これを引用

Nakao, Y., Yoshida, W. Y., Takada, Y., Kimura, J., Yang, L., Mooberry, S. L., & Scheuer, P. J. (2004). Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa. Journal of Natural Products, 67(8), 1332-1340. https://doi.org/10.1021/np049949f

Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa. / Nakao, Youichi; Yoshida, Wesley Y.; Takada, Yuuki; Kimura, Junji; Yang, Liu; Mooberry, Susan L.; Scheuer, Paul J.

:: Journal of Natural Products, 巻 67, 番号 8, 08.2004, p. 1332-1340.

研究成果: Article

Nakao, Y, Yoshida, WY, Takada, Y, Kimura, J, Yang, L, Mooberry, SL & Scheuer, PJ 2004, 'Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa', Journal of Natural Products, 巻. 67, 番号 8, pp. 1332-1340. https://doi.org/10.1021/np049949f
Nakao, Youichi ; Yoshida, Wesley Y. ; Takada, Yuuki ; Kimura, Junji ; Yang, Liu ; Mooberry, Susan L. ; Scheuer, Paul J. / Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa. :: Journal of Natural Products. 2004 ; 巻 67, 番号 8. pp. 1332-1340.
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AU - Yang, Liu

AU - Mooberry, Susan L.

AU - Scheuer, Paul J.

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