Kulolide: A cytotoxic depsipeptide from a cephalaspidean mollusk, Philinopsis speciosa

Michael T. Reese, Nanda K. Gulavita, Yoichi Nakao, Mark T. Hamann, Wesley Y. Yoshida, Stephen J. Coval, Paul J. Scheuer*

*この研究の対応する著者

研究成果査読

58 被引用数 (Scopus)

抄録

Kulolide, a cyclic depsipeptide, was isolated from a cephalaspidean mollusk, Philinopsis speciosa Pease, 1860. Kulolide is made up of five amino acid residues, one each of L-Ala, L-Pro, and N-Me-D-Val and two of L-Val, and two carboxylic acids, L-3-phenyllactic acid and the unprecedented (R)-3-hydroxy-2,2-dimethyl-7-octynoic acid. The kulolide structure was elucidated by spectral techniques and hydrolytic reactions. Kulolide is active against L-1210 leukemia cells and P388 murine leukemia cells at IC50 values of 0.7 and 2.l μg/mL, respectively. Kulolide caused morphological change against rat 3Y1 fibroblast cells at the concentration of 50 μM.

本文言語English
ページ(範囲)11081-11084
ページ数4
ジャーナルJournal of the American Chemical Society
118
45
DOI
出版ステータスPublished - 1996 11 13
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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