Lactate Metabolism and Satellite Cell Fate

Minas Nalbandian*, Zsolt Radak, Masaki Takeda

*この研究の対応する著者

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Lactate is one of the metabolic products of glycolysis. It is widely accepted as an important energy source for many cell types and more recently has been proposed to actively participate in cell-cell communication. Satellite cells (SCs), which are adult skeletal muscle stem cells, are the main players of the skeletal muscle regeneration process. Recent studies have proposed a metabolic switch to increase glycolysis in activated SCs. Moreover, lactate has been shown to affect SCs and myoblasts in vivo and in vitro. In this short review, we describe how metabolic variations relate with SC fate (quiescence, activation, proliferation, migration, differentiation, fusion, and self-renewal), as well as discuss possible relationships between lactate as a metabolite and as a signaling molecule affecting SC fate.

本文言語English
論文番号610983
ジャーナルFrontiers in Physiology
11
DOI
出版ステータスPublished - 2020 12 11
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 生理学(医学)

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