Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults

Nobuhiko Akazawa, Ai Hamasaki, Koichiro Tanahashi, Keisei Kosaki, Toru Yoshikawa, Kanae Myoenzono, Seiji Maeda*

*この研究の対応する著者

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The age-related decrease in cerebral blood flow velocity increases the risk of cerebrovascular disease. Milk protein-derived bioactive peptides, e.g., lactotripeptide (LTP), have been shown to inhibit angiotensin converting enzyme activities and increase vasodilator production. We hypothesized that LTP ingestion increases cerebral blood flow velocity in middle-aged and older adults. In a randomized, placebo-controlled, double-blind design, 15 healthy middle-aged and older adults were assigned to either a LTP group or a placebo group. The subjects ingested LTP or placebo orally for 8 weeks. Before and after intervention, middle cerebral blood flow velocity was measured using transcranial Doppler ultrasonography. The baseline middle cerebral blood flow velocity and most other key dependent variables did not differ between the groups. LTP ingestion significantly increased middle cerebral blood flow velocity, but there was no such improvement in the placebo groups. We concluded that 8 weeks of LTP ingestion increased middle cerebral blood flow velocity in middle-aged and older adults.

本文言語English
ページ(範囲)61-66
ページ数6
ジャーナルNutrition Research
53
DOI
出版ステータスPublished - 2018 5
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学
  • 栄養および糖尿病

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