Lanthanide metal complexes for the hydrolysis of linear DNAs

Tetsuro Shiiba, Koji Yonezawa, Naoya Takeda, Yoichi Matsumoto, Morio Yashiro, Makoto Komiyama

研究成果: Letter

40 引用 (Scopus)

抜粋

Lanthanum (III) and cerium (III) complexes of macrocyclic ligands efficiently hydrolyze the phosphodiester linkages in linear DNAs at pH 7.2 and 30-50°C. Both single-stranded and double-stranded DNAs are hydrolysed without specific base preference, yielding predominantly 3′-phosphate termini. The potential of these complexes as the catalytic centers of artificial hydrolytic nucleases are indicated.

元の言語English
ページ(範囲)L21-L25
ジャーナルJournal of Molecular Catalysis
84
発行部数1
DOI
出版物ステータスPublished - 1993 9 21

ASJC Scopus subject areas

  • Engineering(all)

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