Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines

Jun Nakanishi, Hidekazu Nakayama, Takahiro Shimizu, Haruhisa Ishida, Yukiko Kikuchi, Kazuo Yamaguchi, Yasuhiro Horiike

研究成果: Article査読

51 被引用数 (Scopus)

抄録

A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.

本文言語English
ページ(範囲)3822-3823
ページ数2
ジャーナルJournal of the American Chemical Society
131
11
DOI
出版ステータスPublished - 2009 3 25
外部発表はい

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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