Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.

Makoto Yuasa, Kenichi Oyaizu, Aiko Horiuchi, Akihiko Ogata, Tomomi Hatsugai, Aritomo Yamaguchi, Hiroyoshi Kawakami

研究成果: Article

30 引用 (Scopus)

抜粋

A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.

元の言語English
ページ(範囲)387-389
ページ数3
ジャーナルMolecular pharmaceutics
1
発行部数5
DOI
出版物ステータスPublished - 2004
外部発表Yes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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