抜粋
A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 387-389 |
| ページ数 | 3 |
| ジャーナル | Molecular pharmaceutics |
| 巻 | 1 |
| 発行部数 | 5 |
| DOI | |
| 出版物ステータス | Published - 2004 |
| 外部発表 | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
フィンガープリント Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Yuasa, M., Oyaizu, K., Horiuchi, A., Ogata, A., Hatsugai, T., Yamaguchi, A., & Kawakami, H. (2004). Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs. Molecular pharmaceutics, 1(5), 387-389. https://doi.org/10.1021/mp049936v