抄録
A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 387-389 |
| ページ数 | 3 |
| ジャーナル | Mol Pharm |
| 巻 | 1 |
| 発行部数 | 5 |
| 出版物ステータス | Published - 2004 9 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Molecular Medicine
- Pharmaceutical Science
これを引用
Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs. / Yuasa, Makoto; Oyaizu, Kenichi; Horiuchi, Aiko; Ogata, Akihiko; Hatsugai, Tomomi; Yamaguchi, Aritomo; Kawakami, Hiroyoshi.
：: Mol Pharm, 巻 1, 番号 5, 09.2004, p. 387-389.研究成果: Article
}
TY - JOUR
T1 - Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.
AU - Yuasa, Makoto
AU - Oyaizu, Kenichi
AU - Horiuchi, Aiko
AU - Ogata, Akihiko
AU - Hatsugai, Tomomi
AU - Yamaguchi, Aritomo
AU - Kawakami, Hiroyoshi
PY - 2004/9
Y1 - 2004/9
N2 - A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.
AB - A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.
UR - http://www.scopus.com/inward/record.url?scp=17744398058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17744398058&partnerID=8YFLogxK
M3 - Article
C2 - 16026010
AN - SCOPUS:17744398058
VL - 1
SP - 387
EP - 389
JO - Molecular Pharmaceutics
JF - Molecular Pharmaceutics
SN - 1543-8384
IS - 5
ER -