抄録
A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.
本文言語 | English |
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ページ(範囲) | 387-389 |
ページ数 | 3 |
ジャーナル | Molecular pharmaceutics |
巻 | 1 |
号 | 5 |
DOI | |
出版ステータス | Published - 2004 |
外部発表 | はい |
ASJC Scopus subject areas
- 分子医療
- 薬科学
- 創薬