Loading of curcumin into macrophages using lipid-based nanoparticles

Keitaro Sou, Shunsuke Inenaga, Shinji Takeoka, Eishun Tsuchida

研究成果: Article査読

152 被引用数 (Scopus)

抄録

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Cm) is a natural compound which possesses antioxidant, anti-inflammatory and anti-tumor ability. Here, phospholipid vesicles or lipid-nanospheres embedding Cm (CmVe or CmLn) were formulated to deliver Cm into tissue macrophages through intravenous injection. Cm could be solubilized in hydrophobic regions of these particles to form nanoparticle dispersions, and these formulations showed ability to scavenge reactive oxygen species as antioxidants in dispersions. At 6 h after intravenous injection in rats via the tail vein (2 mg Cm/kg bw), confocal microscopic observations of tissue sections showed that Cm was massively distributed in cells assumed as macrophages into the bone marrow and spleen. Taken together, these results indicate that the lipid-based nanoparticulates provide improved intravenous delivery of Cm to tissues macrophages, specifically bone marrow and splenic macrophages in present formulation, which has therapeutic potential as an antioxidant and anti-inflammatory.

本文言語English
ページ(範囲)287-293
ページ数7
ジャーナルInternational Journal of Pharmaceutics
352
1-2
DOI
出版ステータスPublished - 2008 3 20

ASJC Scopus subject areas

  • Pharmaceutical Science

フィンガープリント 「Loading of curcumin into macrophages using lipid-based nanoparticles」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル