Local spectrum measurement system for 5-aminolaevulinic acid induced protoporphyrin IX fluorescence

Takehiro Ando*, Masafumi Noguchi, Etsuko Kobayashi, Hongen Liao, Takashi Maruyama, Yoshihiro Muragaki, Hiroshi Iseki, Ichiro Sakuma

*この研究の対応する著者

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

We have developed a local spectrum measurement system for 5-Aminolaevulinic acid (5-ALA) induced Protoporphyrin IX (PpIX) fluorescence, which consists of a semiconductor LASER, a CCD spectrometer, a personal computer and a fluorescence measurement probe. Performance evaluation results showed that the probe has sufficient ability to measure PpIX fluorescence with a spatial resolution of about 0.8mm around the working-distance. We used this probe for measurement of resected brain tissues to evaluate discrimination ability of 5-ALA induced PpIX fluorescence. To compare spectrums with pathology, we used a tissue holder to freeze tissues keeping their shape. This procedure enables precise comparison each measured point with pathology. Thirteen samples of brain tissue were measured using the developed system, and the results showed that PpIX fluorescence could be detected in tumor lesion even less than 1mm in diameter. Although some samples shrank to about 80% of holder size, characterized shape enabled to compare spectrums with pathology.

本文言語English
ホスト出版物のタイトルWorld Congress on Medical Physics and Biomedical Engineering
ホスト出版物のサブタイトルDiagnostic Imaging
出版社Springer Verlag
ページ375-378
ページ数4
2
ISBN(印刷版)9783642038785
DOI
出版ステータスPublished - 2009
外部発表はい
イベントWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging - Munich, Germany
継続期間: 2009 9月 72009 9月 12

出版物シリーズ

名前IFMBE Proceedings
番号2
25
ISSN(印刷版)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging
国/地域Germany
CityMunich
Period09/9/709/9/12

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 生体医工学

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