Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line

S. I. Fukushige, K. I. Matsubara, M. Yoshida, M. Sasaki, T. Suzuki, K. Semba, K. Toyoshima, T. Yamamoto

研究成果: Article査読

271 被引用数 (Scopus)

抄録

The c-erbB-2 gene is a v-erbB-related proto-oncogene which is distinct from the gene encoding the epidermal growth factor receptor. By using two independent methods, hybridization of both sorted chromosomes and metaphase spreads with cloned c-erbB-2 DNA, we mapped the c-erbB-2 locus on human chromosome 17 at q21, a specific breakpoint observed in a translocation associated with acute promyelocytic leukemia. Furthermore, we observed amplification and elevated expression of the c-erbB-2 gene in the MKN-7 gastric cancer cell line. These data suggest possible involvement of the c-erbB-2 gene in human cancer.

本文言語English
ページ(範囲)955-958
ページ数4
ジャーナルMolecular and Cellular Biology
6
3
DOI
出版ステータスPublished - 1986
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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