Long-term potentiation in the optic tectum of rainbow trout

Masae Kinoshita, Toshiyuki Hosokawa, Akihisa Urano, Etsuro Ito

研究成果: Article査読

14 被引用数 (Scopus)

抄録

We examined synaptic plasticity in the optic tectum of rainbow trout by extracellular recordings. We found that the field-excitatory postsynaptic potential in the retinotectal synapses was potentiated by repetitive stimuli of 1.0 Hz for 20 s to the retinotectal afferents. The long-term potentiation (LTP) developed slowly, and was maintained for at least 2 h. Applications of an antagonist for N-methyl-d-aspartic acid (NMDA) receptors or Mg 2+-free saline showed that activation of NMDA receptors was required to form the LTP beyond the induction period. The present findings indicate that presynaptic stimulation in the retinotectal synapses causes LTP mediated by NMDA receptors in the optic tectum of rainbow trout.

本文言語English
ページ(範囲)146-150
ページ数5
ジャーナルNeuroscience Letters
370
2-3
DOI
出版ステータスPublished - 2004 11月 11
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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