Long-term prognostic assessment of 185 newly diagnosed gliomas - Grade III glioma showed prognosis comparable to that of grade II glioma

Chie Shinohara, Yoshihiro Muragaki*, Takashi Maruyama, Satoru Shimizu, Masahiko Tanaka, Yuichi Kubota, Mitsuteru Oikawa, Ryoichi Nakamura, Hiroshi Iseki, Osami Kubo, Kintomo Takakura, Tomokatsu Hori

*この研究の対応する著者

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Objective: We evaluated the prognoses of newly diagnosed gliomas through WHO Grades II, III and IV to assess the overall tendency of treatment results for glioma in our institute. Furthermore, statistical analysis was performed to determine factors influencing the prognosis. Methods: A total of 185 newly diagnosed glioma patients were operated on from 2000 to 2006. The primary endpoint was the overall survival from the date of surgery. The factors assessed as to whether they influenced the prognosis were the WHO grades of sex, age, location of the lesion, pre-operative Karnofsky Performance Status (KPS), extent of resection and whether or not radiation therapy was performed. Results: The WHO grades influenced the survival significantly (P < 0.0001). The Grades II and III showed no statistically significant difference in survival (P = 0.174), whereas Grades III and IV showed a significant difference (P < 0.0001). The factor influencing survival as well as the grades was the KPS (P < 0.0001). The comparison of survival over WHO grades in the same KPS group was performed for 2 KPS groups (KPS = 100, KPS 80-90), and these also showed significant differences (P = 0.0009 and 0.0143, respectively). Conclusions: Despite the different distributions of the KPS, the Grade III glioma patients showed survival comparable to that of the Grade II. On the other hand, the Grade IV glioma patients showed significantly poorer survival compared with Grade II or III.

本文言語English
ページ(範囲)730-733
ページ数4
ジャーナルJapanese Journal of Clinical Oncology
38
11
DOI
出版ステータスPublished - 2008
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究

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