Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response

D. L. Alkon, J. V. Sanchez-Andres, E. Ito, K. Oka, T. Yoshioka, C. Collin

研究成果: Article査読

57 被引用数 (Scopus)


For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous γ-aminobutyric acid (GABA) with postsynaptic depolarization or pairing of pre- and postsynaptic stimulation. Current- and voltage-clamp experiments suggest that this synaptic transformation is due to a shift from a net increase of conductance to a net decrease of conductance in response to GABA. GABA-induced elevation of intracellular calcium is prolonged after the same stimulus pairing and may, therefore, contribute to this synaptic transformation via Ca2+- activated phosphorylation pathways. This synaptic transformation, which does not follow unpaired stimulus presentations, occurs in a neuronal compartment spatially separated from the soma, which also changes during stimulus pairing.

ジャーナルProceedings of the National Academy of Sciences of the United States of America
出版ステータスPublished - 1992

ASJC Scopus subject areas

  • General

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