Lordosis-inhibiting effect of progesterone in male and female rats with septal lesions

Motoyasu Satou, Korehito Yamanouchi*

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The inhibitory role of progesterone (P) in regulating lordosis was investigated in male and female rats with septal lesions (SL). Male rats with SL showed lordosis quotients (LQ) as high as female rats with SL and female control rats without brain surgery after injection of 50 μg/kg estradiol benzoate (EB) followed by 0.5 mg P 44 h later. Even when primed with 5 mg P 1 h prior to the 50 μg EB-injection, the mean LQs were still high in all groups. When the dose of EB was decreased to 5 μg/kg, all rats showed high-score LQs. In contrast, all animals in both male and female in which 5 mg P was injected 1 h before 5 μg EB, showed low LQs. These results suggest that P is effective in suppressing lordosis enhanced by estrogen in either male rats or females. Furthermore, the high dose of estrogen overcomes the inhibitory action of P on lordosis in both sexes. (C) 2000 Elsevier Science Inc.

本文言語English
ページ(範囲)331-334
ページ数4
ジャーナルBrain Research Bulletin
53
3
DOI
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 神経科学(全般)

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