Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults

Masaki Takahashi, Masashi Miyashita*, Noriaki Kawanishi, Jong Hwan Park, Harumi Hayashida, Hyun Shik Kim, Yoshio Nakamura, Shizuo Sakamoto, Katsuhiko Suzuki

*この研究の対応する著者

研究成果: Article査読

34 被引用数 (Scopus)

抄録

The purpose of this study was to investigate the effects of low-volume exercise training (100 min/week) on oxidative stress and neutrophils activation markers in older adults. Twenty-eight older adults (age range 65-78 years) were assigned into control (n = 14) or exercise (n = 14) groups. The exercise program consisted of walking 30-60 min/session, 2 days each week for 12 weeks. Blood samples were taken before starting the sessions (baseline) and when they ended. Fasting plasma and serum oxidative stress and inflammatory markers were measured using commercial kits. Cell surface expression of adhesion molecules on circulating leukocytes (CD66b and CD62L) was determined using flow cytometry. The concentrations of derivatives of reactive oxygen metabolites tended to be lower than the baseline values only in the exercise group (P = 0.05). The biological antioxidant potential, thioredoxin concentrations, and glutathione peroxidase activities significantly increased only in the exercise group (P < 0.05 for all). While CD66b expression tended to decrease only in the exercise group, CD62L expression significantly increased (P < 0.05). Our findings indicate that exercise training below the current recommended level of at least 150 min/week attenuates basal oxidative stress and neutrophil activation in older adults. Thus, our findings may encourage more people to incorporate a small amount of physical activity into their lives.

本文言語English
ページ(範囲)1117-1126
ページ数10
ジャーナルEuropean Journal of Applied Physiology
113
5
DOI
出版ステータスPublished - 2013 5

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 公衆衛生学、環境および労働衛生
  • 生理学(医学)

フィンガープリント

「Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル