Lowering effects of allyl isothiocyanate on the number of lymphocyte and its subsets in rats

Kazuhiko Imaizumi*, Yuko Sakakibara, Hiromi Sasaki, Shogo Sato, Yumi Takei, Kaori Hiruma, Takamasa Ban, Yu Kawashima, Jun Tanihata, Kaoru Tachiyashiki


    研究成果: Article査読

    4 被引用数 (Scopus)


    The purpose of this study was to elucidate the effects of a main pungent component of wasabi, allyl isothiocyanate (AITC), on the number of lymphocytes, T-lymphocyte, B-lymphocyte and natural killer (NK) cells and plasma corticosterone concentrations in rats. AITC was given as either single dosage [20mg/kg body weight per day; subcutaneous (s.c.) and oral] or as a daily dosage (10 mg and 20mg/kg body weight per day; s.c.) for 4 days for the hourly and daily assessment of changes in the numbers of lymphocytes, respectively. A single s.c. injection or oral administration of AITC significantly reduced the number of lymphocytes at 4 hr to approximately 0.68 times, indicating that decreased effects of AITC on the number of lymphocytes are independent on the administration route. Administration of AITC for 4 days reduced dose-dependently the number of lymphocytes, and significantly reduced the number of T-lymphocyte and B-lymphocyte to 0.79 and 0.60 times, respectively. However, the number of NK cells did not change by AITC. Administration of AITC increased plasma corticosterone concentrations at 4 day of post s.c. injection to 5.4-6.0 times. These results suggest that AITC-mediated immunosuppresion is at least in part attributable to changes in the number and distribution of lymphocyte and its subsets.

    ジャーナルJournal of Health Science
    出版ステータスPublished - 2010 6月

    ASJC Scopus subject areas

    • 毒物学
    • 健康、毒物学および変異誘発


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