Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1

Zsolt Radak*, Sataro Goto, Hideko Nakamoto, Katalin Udud, Zsolt Papai, Ildiko Horvath

*この研究の対応する著者

研究成果: Article査読

19 被引用数 (Scopus)

抄録

N-Glycosylases excise the damaged adducts from DNA. 7,8-Dihydro-8- oxoguanine in human cells is repaired by OGG1 and hNTH1. The activities of hOGG1 and hNTH1 were measured, using modified and 32P labelled oligonucleotides, in bronchial biopsy samples of smoking patients with non-small cell lung carcinoma. The activity of hOOG1 was significantly higher in biopsies from tumour tissues compared with intra-individual control samples. On the contrary, the activity of endonuclease III homologue, hNTH1, was lower in tumours compared to controls. These opposing alterations in DNA repair enzymes may affect cancer growth due to the increased formation of AP sites.

本文言語English
ページ(範囲)191-195
ページ数5
ジャーナルCancer Letters
219
2
DOI
出版ステータスPublished - 2005 3月 10
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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