Macrocycles Derived from Cinchona Alkaloids: A Thermodynamic vs Kinetic Study

Stuart J. Rowan, Jeremy K M Sanders

研究成果: Article査読

67 被引用数 (Scopus)

抄録

Cyclization of the quinine-derived monomer (2a): HO-Cq-OMe, under thermodynamic control, gives mainly cyclic trimer Cq3 (7a), whereas kinetic cyclization of the similar monomer HO-Cq-OH (8) gives a mixture of cyclic products. This difference in product distribution is attributed to predisposition of the monomer unit, which means the building block adopts a more stable conformation in cyclic trimer than it can in cyclic tetramer. The reversibility of the thermodynamic reaction was demonstrated using electrospray mass spectrometry to monitor the catalyzed mixing of the two cyclic trimers Cq3 (7a) and Cc3 (7b), which results in the statistically expected 1:3:3:1 ratio of all possible cyclic trimers Cc3:Cc2Cq:CcCq2:Cq3.

本文言語English
ページ(範囲)1536-1546
ページ数11
ジャーナルJournal of Organic Chemistry
63
5
出版ステータスPublished - 1998 3 6
外部発表はい

ASJC Scopus subject areas

  • Organic Chemistry

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