Mangromicins A and B: Structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216

Takuji Nakashima*, Masato Iwatsuki, Junya Ochiai, Yoshiyuki Kamiya, Kenichiro Nagai, Atsuko Matsumoto, Aki Ishiyama, Kazuhiko Otoguro, Kazuro Shiomi, Yoko Takahashi, Satoshi Omura

*この研究の対応する著者

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Two new cyclopentadecane antibiotics, named mangromicins A and B, were separated out from the culture broth of Lechevalieria aerocolonigenes K10-0216 by Diaion HP-20, silica gel and ODS column chromatography, and were finally purified by HPLC. The chemical structures of the two novel compounds were elucidated by instrumental analyses, including various NMR, MS and X-ray crystallography. Mangromicins A and B consist of cyclopentadecane skeletons with a tetrahydrofuran unit and a 5,6-dihydro-4-hydroxy-2-pyrone moiety. Mangromicins A and B showed in vitro antitrypanosomal activity with IC 50 values of 2.4 and 43.4 μg ml -1, respectively. The IC 50 values of both compounds were lower than those of cytotoxicity against MRC-5 human fetal lung fibroblast cells.

本文言語English
ページ(範囲)253-260
ページ数8
ジャーナルJournal of Antibiotics
67
3
DOI
出版ステータスPublished - 2014 3
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

フィンガープリント

「Mangromicins A and B: Structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル