Marked reduction of acyl-CoA synthetase activity and mRNA in intra- abdominal visceral fat by physical exercise

I. Shimomura*, K. Tokunaga, K. Kotani, Y. Keno, M. Yanase-Fujiwara, K. Kanosue, S. Jiao, T. Funahashi, T. Kobatake, T. Yamamoto, Y. Matsuzawa

*この研究の対応する著者

研究成果: Article査読

62 被引用数 (Scopus)

抄録

Several reports have suggested that the reduction of intra-abdominal visceral fat after physical exercise is more prominent than that of subcutaneous fat. We compared some parameters in mesenteric and subcutaneous fats between sedentary and exercised rats (treadmill running; 10-20 m/min, 60 min/day, 7 days). Tissue weight and cell volume were decreased in mesenteric fat by the exercise. The exercise reduced activity and mRNA levels of acyl- CoA synthetase (ACS; 67 and 26% of those of the sedentary group, respectively), mRNA levels of lipoprotein lipase (LPL; 49% of those of the sedentary group), and GLUT-4 (38% of those of the sedentary group) in the mesenteric fat. In contrast, all of these parameters did not change significantly in the subcutaneous fat. Gastrocnemius muscle was heavier in exercised rats. ACS activity was elevated in the gastrocnemius muscle of the exercised rats (137% of those of sedentary group), although mRNA levels of ACS, LPL, and GLUT-4 did not change in the muscle by the exercise. These observations suggest that mesenteric fat may contribute to switching of distribution of plasma energy flux, including lipid and glucose, from fat tissue to muscle in physical exercise.

本文言語English
ページ(範囲)E44-E50
ジャーナルAmerican Journal of Physiology - Endocrinology and Metabolism
265
1 28-1
出版ステータスPublished - 1993 1 1
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生理学
  • 生理学(医学)

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