Massive Fabrication of Polymer Microdiscs by Phase Separation and Freestanding Process

Hong Zhang, Mao Fujii, Yosuke Okamura, Li Zhang, Shinji Takeoka

    研究成果: Article

    4 引用 (Scopus)

    抜粋

    We present a facile method to fabricate polymer thin films with tens of nanometers thickness and several micrometers size (also called "microdiscs" herein) by applying phase separation of polymer blend. A water-soluble supporting layer is employed to obtain a freestanding microdisc suspension. Owing to their miniaturized size, microdiscs can be injected through a syringe needle. Herein, poly(d,l-lactic acid) microdiscs were fabricated with various thicknesses and sizes, in the range from ca. 10 to 60 nm and from ca. 1.0 to 10.0 μm, respectively. Magnetic nanoparticles were deposited on polymer microdiscs with a surface coating method. The magnetic manipulation of microdiscs in a liquid environment under an external magnetic field was achieved with controllable velocity by adjusting the microdisc dimensions and the loading amount of magnetic components. Such biocompatible polymer microdiscs are expected to serve as injectable vehicles for targeted drug delivery.

    元の言語English
    ページ(範囲)16296-16302
    ページ数7
    ジャーナルACS Applied Materials and Interfaces
    8
    発行部数25
    DOI
    出版物ステータスPublished - 2016 6 29

    ASJC Scopus subject areas

    • Materials Science(all)

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