Massive Fabrication of Polymer Microdiscs by Phase Separation and Freestanding Process

Hong Zhang, Mao Fujii, Yosuke Okamura, Li Zhang, Shinji Takeoka*

*この研究の対応する著者

研究成果: Article査読

8 被引用数 (Scopus)

抄録

We present a facile method to fabricate polymer thin films with tens of nanometers thickness and several micrometers size (also called "microdiscs" herein) by applying phase separation of polymer blend. A water-soluble supporting layer is employed to obtain a freestanding microdisc suspension. Owing to their miniaturized size, microdiscs can be injected through a syringe needle. Herein, poly(d,l-lactic acid) microdiscs were fabricated with various thicknesses and sizes, in the range from ca. 10 to 60 nm and from ca. 1.0 to 10.0 μm, respectively. Magnetic nanoparticles were deposited on polymer microdiscs with a surface coating method. The magnetic manipulation of microdiscs in a liquid environment under an external magnetic field was achieved with controllable velocity by adjusting the microdisc dimensions and the loading amount of magnetic components. Such biocompatible polymer microdiscs are expected to serve as injectable vehicles for targeted drug delivery.

本文言語English
ページ(範囲)16296-16302
ページ数7
ジャーナルACS Applied Materials and Interfaces
8
25
DOI
出版ステータスPublished - 2016 6月 29

ASJC Scopus subject areas

  • 材料科学(全般)

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