Mechanically adaptive nanocomposites for neural interfacing

Jeffrey R. Capadona, Dustin J. Tyler, Christian A. Zorman, Stuart J. Rowan, Christoph Weder

研究成果: Article

57 引用 (Scopus)

抜粋

The recording of neural signals with microelectrodes that are implanted into the cortex of the brain is potentially useful for a range of clinical applications. However, the widespread use of such neural interfaces has so far been stifled because existing intracortical electrode systems rarely allow for consistent long-term recording of neural activity. This limitation is usually attributed to scar formation and neuron death near the surface of the implanted electrode. It has been proposed that the mechanical property mismatch between existing electrode materials and the brain tissue is a significant contributor to these events. To alleviate this problem, we utilized the architecture of the sea cucumber dermis as a blueprint to engineer a new class of mechanically adaptive materials as substrates for â œsmartâ intracortical electrodes. We demonstrated that these originally rigid polymer nanocomposites soften considerably upon exposure to emulated physiological and in vivo conditions. The adaptive nature of these bioinspired materials makes them useful as a basis for electrodes that are sufficiently stiff to be easily implanted and subsequently soften to better match the stiffness of the brain. Initial histological evaluations suggest that mechanically adaptive neural prosthetics can more rapidly stabilize neural cell populations at the device interface than rigid systems, which bodes well for improving the functionality of intracortical devices.

元の言語English
ページ(範囲)581-589
ページ数9
ジャーナルMRS Bulletin
37
発行部数6
DOI
出版物ステータスPublished - 2012 6
外部発表Yes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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    Capadona, J. R., Tyler, D. J., Zorman, C. A., Rowan, S. J., & Weder, C. (2012). Mechanically adaptive nanocomposites for neural interfacing. MRS Bulletin, 37(6), 581-589. https://doi.org/10.1557/mrs.2012.97