Mechanism for the posture-specific plasma volume increase after a single intense exercise protocol

Kei Nagashima, Gary W. Mack*, Andrew Haskell, Takeshi Nishiyasu, Ethan R. Nadel

*この研究の対応する著者

研究成果: Article査読

39 被引用数 (Scopus)

抄録

To test the hypothesis that exercise-induced hypervolemia is a posture- dependent process, we measured plasma volume, plasma albumin content, and renal function in seven healthy subjects for 22 h after single upright (Up) or supine (Sup) intense (85% peak oxygen consumption rate) exercise. This posture was maintained for 5 h after exercise. Plasma volume decreased during exercise but returned to control levels by 5 h of recovery in both postures. By 22 h of recovery, plasma volume increased 2.4 ± 0.8 ml/kg in Up but decreased 2.1 ± 0,8 ml/kg in Sup. The plasma volume expansion in Up was accompanied by an increase in plasma albumin content (0.11 ± 0.04 g/kg; P < 0.05). Plasma albumin content was unchanged in Sup. Urine volume and sodium clearance were lower in Up than Sup (P < 0.05) by 5 h of recovery. These data suggest that increased plasma albumin content contributes to the acute phase of exercise-induced hypervolemia. More importantly, the mechanism by which exercise influences the distribution of albumin between extra- and intravascular stores after exercise is altered by posture and is unknown. We speculate that factors associated with postural changes (e.g., central venous pressure) modify the increase in plasma albumin content and the plasma volume expansion after exercise.

本文言語English
ページ(範囲)867-873
ページ数7
ジャーナルJournal of Applied Physiology
86
3
DOI
出版ステータスPublished - 1999 3月
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 生理学(医学)

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