抄録
Direct C-H phenylation of 2-ethylthiophene and 2-chlorothiophene with PhPdI(bipy) complex to form either the corresponding 4-phenyl or 5-phenylthiophene derivative is studied under stoichiometric conditions using various Lewis acids as additives. It is shown that reactions occur via the corresponding cationic Pd complex (PhPdbipy +) and that the counteranion determines the regioselectivity. High-level DFT calculations reveal that C-C bond formation occurs via a carbopalladation pathway and not via electrophilic palladation. These calculations give some indications regarding the regioselectivity of the thiophene arylation.
本文言語 | English |
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ページ(範囲) | 1256-1260 |
ページ数 | 5 |
ジャーナル | Chemistry - An Asian Journal |
巻 | 7 |
号 | 6 |
DOI | |
出版ステータス | Published - 2012 6月 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 有機化学