Megakaryocyte growth and development factor: Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy- induced thrombocytopenia

J. L. Nichol, M. M. Hokom, A. Hornkohl, W. P. Sheridan, H. Ohashi, T. Kato, Sheng Li Yue Sheng Li, T. D. Bartley, E. Choi, J. Bogenberger, J. D. Skrine, A. Knudten, J. Chen, G. Trail, L. Sleeman, S. Cole, G. Grampp, P. Hunt

研究成果: Article査読

187 被引用数 (Scopus)

抄録

The present study shows that recombinant human megakaryocyte growth and development factor (r-HuMGDF) behaves both as a megakaryocyte colony stimulating factor and as a differentiation factor in human progenitor cell cultures. Megakaryocyte colony formation induced with r-HuMGDF is synergistically affected by stem cell factor but not by interleukin 3. Megakaryocytes stimulated with r-HuMGDF demonstrate progressive cytoplasmic and nuclear maturation. Measurable levels of megakaryocyte growth and development factor in serum from patients undergoing myeloablative therapy and transplantation are shown to be elaborated in response to thrombocytopenic stress. These data support the concept that megakaryocyte growth and development factor is a physiologically regulated cytokine that is capable of supporting several aspects of megakaryopoiesis.

本文言語English
ページ(範囲)2973-2978
ページ数6
ジャーナルJournal of Clinical Investigation
95
6
DOI
出版ステータスPublished - 1995

ASJC Scopus subject areas

  • Medicine(all)

フィンガープリント 「Megakaryocyte growth and development factor: Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy- induced thrombocytopenia」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル