Megakaryocyte growth and development factor: Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy- induced thrombocytopenia

J. L. Nichol, M. M. Hokom, A. Hornkohl, W. P. Sheridan, H. Ohashi, T. Kato, Sheng Li Yue Sheng Li, T. D. Bartley, E. Choi, J. Bogenberger, J. D. Skrine, A. Knudten, J. Chen, G. Trail, L. Sleeman, S. Cole, G. Grampp, P. Hunt

研究成果: Article

185 引用 (Scopus)

抜粋

The present study shows that recombinant human megakaryocyte growth and development factor (r-HuMGDF) behaves both as a megakaryocyte colony stimulating factor and as a differentiation factor in human progenitor cell cultures. Megakaryocyte colony formation induced with r-HuMGDF is synergistically affected by stem cell factor but not by interleukin 3. Megakaryocytes stimulated with r-HuMGDF demonstrate progressive cytoplasmic and nuclear maturation. Measurable levels of megakaryocyte growth and development factor in serum from patients undergoing myeloablative therapy and transplantation are shown to be elaborated in response to thrombocytopenic stress. These data support the concept that megakaryocyte growth and development factor is a physiologically regulated cytokine that is capable of supporting several aspects of megakaryopoiesis.

元の言語English
ページ(範囲)2973-2978
ページ数6
ジャーナルJournal of Clinical Investigation
95
発行部数6
DOI
出版物ステータスPublished - 1995 1 1

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ASJC Scopus subject areas

  • Medicine(all)

これを引用

Nichol, J. L., Hokom, M. M., Hornkohl, A., Sheridan, W. P., Ohashi, H., Kato, T., Yue Sheng Li, S. L., Bartley, T. D., Choi, E., Bogenberger, J., Skrine, J. D., Knudten, A., Chen, J., Trail, G., Sleeman, L., Cole, S., Grampp, G., & Hunt, P. (1995). Megakaryocyte growth and development factor: Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy- induced thrombocytopenia. Journal of Clinical Investigation, 95(6), 2973-2978. https://doi.org/10.1172/JCI118005