Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura, Shigeru Miyaki, Hiroyuki Ishitobi, Sho Matsuyama, Tomoyuki Nakasa, Naosuke Kamei, Takayuki Akimoto, Yukihito Higashi, Mitsuo Ochi

研究成果: Article

135 引用 (Scopus)

抄録

Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

元の言語English
記事番号37090
ページ(範囲)1257-1265
ページ数9
ジャーナルFEBS Letters
589
発行部数11
DOI
出版物ステータスPublished - 2015 5 8
外部発表Yes

Fingerprint

Exosomes
Stem cells
Mesenchymal Stromal Cells
Muscle
Regeneration
Skeletal Muscle
Muscles
Muscle Development
MicroRNAs
Mesenchymal Stem Cell Transplantation
Repair
Tissue regeneration
Cytokines
Wounds and Injuries

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology
  • Medicine(all)

これを引用

Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., ... Ochi, M. (2015). Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Letters, 589(11), 1257-1265. [37090]. https://doi.org/10.1016/j.febslet.2015.03.031

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. / Nakamura, Yoshihiro; Miyaki, Shigeru; Ishitobi, Hiroyuki; Matsuyama, Sho; Nakasa, Tomoyuki; Kamei, Naosuke; Akimoto, Takayuki; Higashi, Yukihito; Ochi, Mitsuo.

:: FEBS Letters, 巻 589, 番号 11, 37090, 08.05.2015, p. 1257-1265.

研究成果: Article

Nakamura, Y, Miyaki, S, Ishitobi, H, Matsuyama, S, Nakasa, T, Kamei, N, Akimoto, T, Higashi, Y & Ochi, M 2015, 'Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration', FEBS Letters, 巻. 589, 番号 11, 37090, pp. 1257-1265. https://doi.org/10.1016/j.febslet.2015.03.031
Nakamura Y, Miyaki S, Ishitobi H, Matsuyama S, Nakasa T, Kamei N その他. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Letters. 2015 5 8;589(11):1257-1265. 37090. https://doi.org/10.1016/j.febslet.2015.03.031
Nakamura, Yoshihiro ; Miyaki, Shigeru ; Ishitobi, Hiroyuki ; Matsuyama, Sho ; Nakasa, Tomoyuki ; Kamei, Naosuke ; Akimoto, Takayuki ; Higashi, Yukihito ; Ochi, Mitsuo. / Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. :: FEBS Letters. 2015 ; 巻 589, 番号 11. pp. 1257-1265.
@article{247d4f8ec3a646c5a40fdd9a844f51ee,
title = "Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration",
abstract = "Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.",
keywords = "Exosome, Mesenchymal stem cell, MicroRNA, Regeneration, Skeletal muscle",
author = "Yoshihiro Nakamura and Shigeru Miyaki and Hiroyuki Ishitobi and Sho Matsuyama and Tomoyuki Nakasa and Naosuke Kamei and Takayuki Akimoto and Yukihito Higashi and Mitsuo Ochi",
year = "2015",
month = "5",
day = "8",
doi = "10.1016/j.febslet.2015.03.031",
language = "English",
volume = "589",
pages = "1257--1265",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "11",

}

TY - JOUR

T1 - Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

AU - Nakamura, Yoshihiro

AU - Miyaki, Shigeru

AU - Ishitobi, Hiroyuki

AU - Matsuyama, Sho

AU - Nakasa, Tomoyuki

AU - Kamei, Naosuke

AU - Akimoto, Takayuki

AU - Higashi, Yukihito

AU - Ochi, Mitsuo

PY - 2015/5/8

Y1 - 2015/5/8

N2 - Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

AB - Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

KW - Exosome

KW - Mesenchymal stem cell

KW - MicroRNA

KW - Regeneration

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=84936766922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84936766922&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2015.03.031

DO - 10.1016/j.febslet.2015.03.031

M3 - Article

C2 - 25862500

AN - SCOPUS:84936766922

VL - 589

SP - 1257

EP - 1265

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 11

M1 - 37090

ER -