Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura*, Shigeru Miyaki, Hiroyuki Ishitobi, Sho Matsuyama, Tomoyuki Nakasa, Naosuke Kamei, Takayuki Akimoto, Yukihito Higashi, Mitsuo Ochi

*この研究の対応する著者

研究成果: Article査読

337 被引用数 (Scopus)

抄録

Abstract Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

本文言語English
論文番号37090
ページ(範囲)1257-1265
ページ数9
ジャーナルFEBS Letters
589
11
DOI
出版ステータスPublished - 2015 5月 8
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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