Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest

H. Fukuoka*, M. Kiriyama, Y. Nishimura, M. Higurashi, Y. Suzuki, A. Gunji

*この研究の対応する著者

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Immobilization induces abnormal bone metabolism and rapid decalcification. Measurements of bone mineral content disclosed rapid decalcification, especially in lumbar vertebral and metacarpal bones in our short-term 20-day bed rest study. Many factors could contribute to the marked demineralization. The activities of osteoclasts and osteoblasts were studied by following serum levels of tartrate-resistant acid phosphatase and alkaline phosphatase, biomarkers for osteocyte activity. There were no alterations in these enzymes during bed rest. However, urinary excretion of pyridinium cross-links, resorption markers of bone matrix itself, increased by day 10 with subsequent decrease at day 20. So decalcification was induced without any relation to osteoclast activity. As cytokines strongly modulate the function of osteoclasts, peripheral monocyte release of interleukin 1 α and tumor necrosis factor α were assayed to determine the contribution to this rapid demineralization. Cytokines were released transiently by day 7 and later rapidly decreased. However, there was no correlation between cytokine release and bone matrix resorption.

本文言語English
ページ(範囲)37-41
ページ数5
ジャーナルActa Physiologica Scandinavica, Supplement
150
616
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 生理学

フィンガープリント

「Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル