Metabolic turnover of bone during pregnancy and puerperium

M. Haruna*, H. Fukuoka

*この研究の対応する著者

研究成果査読

3 被引用数 (Scopus)

抄録

It has been considered that bone mass is usually maintained during pregnancy by high level of estrogens but drastic decrease of estrogens lead to bone loss during lactation. Metabolic turnover of bone during pregnancy and in puerperium was studied by analyzing biomarkers of bone turnover and cytokine released by peripheral blood mononuclear cells. Urinary excretion of pyridinoline (Pyr) and deoxypyridinoline (D-Pyr), and serum tartrate resistant acid phosphatase (TrACP), which are biomarkers of bone resorption, were increased in the last trimester of pregnancy. Plasma level of intact osteocalcin (I-OC), which is a biomarker of bone formation, decreased in the 2nd trimester and slightly increased in the 3rd. Tumor necrosis factor (TNF)- alpha, which is one of cytokines to stimulate bio-activity of osteoclast, increased during pregnancy. According to these results, we conclude that decrease in bone mass begins already during pregnancy despite of a high estrogen state.

本文言語English
ページ(範囲)109-115
ページ数7
ジャーナルBulletin of the Physical Fitness Research Institute
91
出版ステータスPublished - 1996
外部発表はい

ASJC Scopus subject areas

  • 生理学

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