Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila

Gerrit Loch, Eva Jentgens, Margret Bülow, Ingo Zinke, Tetsushi Mori, Sayaka Suzuki, Haruko Takeyama, Michael Hoch

    研究成果: Chapter

    2 被引用数 (Scopus)


    Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.

    ホスト出版物のタイトルInnate Immunity: Resistance and Disease-Promoting Principles
    出版社S. Karger AG
    ISBN(印刷版)9783318023480, 9783318023473
    出版ステータスPublished - 2013 6 5

    ASJC Scopus subject areas

    • Medicine(all)
    • Immunology and Microbiology(all)
    • Biochemistry, Genetics and Molecular Biology(all)

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