Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila

Gerrit Loch, Eva Jentgens, Margret Bülow, Ingo Zinke, Tetsushi Mori, Sayaka Suzuki, Haruko Takeyama, Michael Hoch*

*この研究の対応する著者

研究成果: Chapter

3 被引用数 (Scopus)

抄録

Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.

本文言語English
ホスト出版物のタイトルInnate Immunity
ホスト出版物のサブタイトルResistance and Disease-Promoting Principles
出版社S. Karger AG
ページ103-111
ページ数9
4
ISBN(電子版)9783318023480
ISBN(印刷版)9783318023473
DOI
出版ステータスPublished - 2013 6月 5

ASJC Scopus subject areas

  • 医学(全般)
  • 免疫学および微生物学(全般)
  • 生化学、遺伝学、分子生物学(全般)

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