Metabolites as clock hands: Estimation of internal body time using blood metabolomics

Hitoshi Iuchi, Rikuhiro G. Yamada, Hiroki R. Ueda

研究成果: Chapter

抄録

The circadian clock governs body time and regulates many physiological functions including sleep and wake cycles, body temperature, feeding, and hormone secretion. Alignment of drug dosing time to body time can maximize the pharmacological effect and minimize untoward effects. Therefore, a simple and robust method for estimating body time is important for drug efficacy or “chronotherapy”. We previously reported that a metabolite timetable could estimate body time with good accuracy. A metabolite timetable was constructed by profiling metabolites in human and mouse with capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography–mass spectrometry (LC-MS). In this chapter, we describe practical methods to profile and identify oscillating metabolites.

本文言語English
ホスト出版物のタイトルNeuromethods
出版社Humana Press Inc.
ページ245-254
ページ数10
DOI
出版ステータスPublished - 2016
外部発表はい

出版物シリーズ

名前Neuromethods
105
ISSN(印刷版)0893-2336
ISSN(電子版)1940-6045

ASJC Scopus subject areas

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 薬理学、毒性学および薬学(全般)
  • 精神医学および精神衛生

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