Metal-assisted stabilization and probing of collagenous triple helices

Takaki Koide*, Maki Yuguchi, Mayuka Kawakita, Hiroyuki Konno

*この研究の対応する著者

研究成果: Article査読

65 被引用数 (Scopus)

抄録

Collagen model peptides that contain 2,2′-bipyridyl (bpy) ligands were designed and synthesized. The thermal stability of the collagenous triple helix was increased by forming an FeII(bpy-peptide)3 complex. The chirality of the metal center was shifted to form right-handed Δ-isomers induced by the supercoiling of the peptide moiety. Moreover, the refolding rate of the triple helix was increased in the presence of Fe(II). This metal-coordinating system possesses potential to be used to stabilize the triple-helical conformation as well as to probe the folding status of collagen model peptides.

本文言語English
ページ(範囲)9388-9389
ページ数2
ジャーナルJournal of the American Chemical Society
124
32
DOI
出版ステータスPublished - 2002 8月 14
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

フィンガープリント

「Metal-assisted stabilization and probing of collagenous triple helices」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル