Metal-free oxidative amide formation with N-hydroxysuccinimide and hypervalent iodine reagents

Haoyi Yao, Yun Tang, Kana Yamamoto

研究成果: Article査読

35 被引用数 (Scopus)

抄録

An oxidative amide formation using N-hydroxysuccinimide and hypervalent iodine reagents was developed. The method enables a wide range of aldehydes and amines to be coupled under mild reaction conditions providing amide in good to excellent yield. The radical species in the reaction mixture was observed for the first time using ESR measurement, and along with other mechanistic investigations, a plausible mechanism of the reaction was proposed.

本文言語English
ページ(範囲)5094-5098
ページ数5
ジャーナルTetrahedron Letters
53
38
DOI
出版ステータスPublished - 2012 9 19
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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