Methamphetamine-induced sensitization of dopamine release via a metabotropic glutamate receptor mediated pathway in rat striatal slices

Ikumi Arai, Takao Shimazoe, Shigenobu Shibata, Hirotaka Inoue, Akiko Yoshimatsu, Shigenori Watanabe

研究成果: Article

10 引用 (Scopus)

抜粋

We studied the roles of metabotropic glutamate receptors in methamphetamine (MAP)-induced sensitization of dopamine (DA) release from striatal slices. Rats were first treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days. After a 6-day withdrawal, DA release from striatal slices evoked by ±-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD) was measured. trans-ACPD-induced DA release was significantly enhanced in MAP-sensitized rats, but the inactive form of trans-ACPD (1R,3S-ACPD) did not enhance DA release. The active form of trans-ACPD (1S,3R-ACPD) (0.1 mM)-evoked DA release was attenuated by treatment with 0.4 mM RS-α-methyl-4-carboxyphenylglycine, a metabotropic glutamate receptor antagonist. The present results suggest that metabotropic glutamate receptors play an important role in expression of MAP-induced sensitization.

元の言語English
ページ(範囲)243-246
ページ数4
ジャーナルJapanese Journal of Pharmacology
73
発行部数3
DOI
出版物ステータスPublished - 1997 3

ASJC Scopus subject areas

  • Pharmacology

フィンガープリント Methamphetamine-induced sensitization of dopamine release via a metabotropic glutamate receptor mediated pathway in rat striatal slices' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用