Methylation in embryonic stem cells in vitro.

Koichiro Nishino, Jun Ohgane, Masako Suzuki, Naka Hattori, Kunio Shiota

研究成果: Article

2 引用 (Scopus)

抜粋

Stem cells raise the possibility of regenerating failing body parts with new tissue. Before stem cells can safely fulfill their promise, many technical problems, including understanding the stem cell phenotype, must be overcome. DNA methylation, which is responsible for gene silencing and is associated with chromatin remodeling, is an epigenetic system that determines the specific characteristic of a variety of cells, including stem cells. Each cell type has a unique DNA methylation profile produced by varied loci-specific methylation. Investigation of such DNA methylation profiles provides a way of identifying pluripotent stem cells. Further, it is likely that analysis of the epigenetic status of stem cells may provide novel information regarding "sternness" within these populations.

元の言語English
ページ(範囲)421-445
ページ数25
ジャーナルMethods in molecular biology (Clifton, N.J.)
329
出版物ステータスPublished - 2006
外部発表Yes

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

これを引用

Nishino, K., Ohgane, J., Suzuki, M., Hattori, N., & Shiota, K. (2006). Methylation in embryonic stem cells in vitro. Methods in molecular biology (Clifton, N.J.), 329, 421-445.