Michael addition reactions in macromolecular design for emerging technologies

Brian D. Mather, Kalpana Viswanathan, Kevin M. Miller, Timothy Edward Long

研究成果: Review article査読

753 被引用数 (Scopus)

抄録

The Michael addition reaction is a versatile synthetic methodology for the efficient coupling of electron poor olefins with a vast array of nucleophiles. This review outlines the role of the Michael addition reaction in polymer synthesis with attention to applications in emerging technologies including biomedical, pharmaceutical, optoelectronic, composites, adhesives, and coatings. Polymer architectures, which broadly range from linear thermoplastics to hyperbranched polymers and networks are achievable. The versatility of the Michael reaction in terms of monomer selection, solvent environment, and reaction temperature permits the synthesis of sophisticated macromolecular structures under conditions where other reaction processes will not operate. The utility of the Michael addition in many biological applications such as gene delivery, polymer drug conjugates, and tissue scaffolds is discussed in relation to macromolecular structure.

本文言語English
ページ(範囲)487-531
ページ数45
ジャーナルProgress in Polymer Science (Oxford)
31
5
DOI
出版ステータスPublished - 2006 5 1
外部発表はい

ASJC Scopus subject areas

  • セラミックおよび複合材料
  • 表面および界面
  • ポリマーおよびプラスチック
  • 有機化学
  • 材料化学

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