Microfluidics assisted synthesis of well-defined spherical polymeric microcapsules and their utilization as potential encapsulants

Sinoj Abraham, Eun Ho Jeong, Takahiro Arakawa, Shuichi Shoji, Kyung Chun Kim, Il Kim*, Jeung Sang Go

*この研究の対応する著者

研究成果査読

56 被引用数 (Scopus)

抄録

In this article, the development of a novel technique to fabricate spherical polymeric microcapsules by utilizing microfluidic technology is presented. Atom transfer radical polymerization (ATRP) was employed to synthesize well-defined amphiphilic block copolymers. An organic polymer solution was constrained to adopt the spherical droplets in a continuous water phase at a T-junction microchannel, and the generation of the droplets was studied quantitatively. The flow conditions of two immiscible solutions were adjusted for the successful generation of the polymer droplets. The morphology of the microcapsules was examined. The efficiency of these polymer microcapsules as containers for the storage and controlled release of loaded molecules was evaluated by encapsulating the microcapsules with Congo-red dye and investigating the release performance using temperature controlled UV-VIS spectroscopy.

本文言語English
ページ(範囲)752-756
ページ数5
ジャーナルLab on a Chip
6
6
DOI
出版ステータスPublished - 2006 1 1

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 生化学
  • 化学 (全般)
  • 生体医工学

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