Microparticle Responses to Aerobic Exercise and Meal Consumption in Healthy Men

Patrick J. Highton, Fernanda R. Goltz, Naomi Martin, David J. Stensel, Alice E. Thackray, Nicolette C. Bishop*

*この研究の対応する著者

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Purpose Microparticles (MP) are shed extracellular vesicles that express the prothrombotic tissue factor (TF). Aerobic exercise may reduce MP count and TF expression. This study investigated the impact of acute running or rest followed by standardized meal consumption on MP phenotypes and TF expression. Methods Fifteen males (age, 22.9 ± 3.3 yr; body mass, 81.9 ± 11.4 kg; VO2max, 54.9 ± 6.5 mL·kg-1·min-1; mean ± SD) completed 1 h of running (70% VO2max) or rest at 9:00 am and consumed a standardized meal (1170 kcal, 43% CHO, 17% PRO, 40% fat) at 10:45 am. Venous blood samples were taken at 9:00 am, 10:00 am, and 11:30 am. The MP concentration, diameter, phenotypes, and TF expression were assessed using nanoparticle tracking analysis and flow cytometry. Results Nanoparticle tracking analysis identified no changes in MP concentration or diameter in response to time or trial. Flow cytometry revealed total MP count increased from 9:00 am to 10:00 am (1.62 ± 2.28 to 1.74 ± 2.61 × 1010 L-1, P = 0.016, effect size (η2) = 0.105), but was unaffected by trial. TF+ platelet-derived MP % reduced from 9:00 am to 10:00 am (44.0% ± 21.2% to 21.5% ± 9.3%, P = 0.001, η2 = 0.582) after exercise only (control, 36.8% ± 18.2% to 34.9% ± 11.9%; P = 0.972). TF+ neutrophil-derived MP percentage reduced from 9:00 am to 11:30 am (42.3% ± 17.2% to 25.1% ± 14.9%; P = 0.048, η2 = 0.801) in the exercise trial only (control, 28.5% ± 15.7% to 32.2% ± 9.6%; P = 0.508). Conclusions Running induced a significant reduction in %TF+ platelet and neutrophil MP, suggesting a transient reduction in cardiovascular risk via reduced TF-stimulated thrombosis. This requires further investigation over longer periods in cardiovascular disease populations.

本文言語English
ページ(範囲)1935-1943
ページ数9
ジャーナルMedicine and Science in Sports and Exercise
51
9
DOI
出版ステータスPublished - 2019 9月 1
外部発表はい

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 理学療法、スポーツ療法とリハビリテーション

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