Microporous membrane-based liver tissue engineering for the reconstruction of three-dimensional functional liver tissues in vitro.

Junichi Kasuya*, Kazuo Tanishita

*この研究の対応する著者

研究成果: Article査読

9 被引用数 (Scopus)

抄録

To meet the increasing demand for liver tissue engineering, various three-dimensional (3D) liver cell culture techniques have been developed. Nevertheless, conventional liver cell culture techniques involving the suspending cells in extracellular matrix (ECM) components and the seeding of cells into 3D biodegradable scaffolds have an intrinsic shortcoming, low cell-scaffold ratios. We have developed a microporous membrane-based liver cell culture technique. Cell behaviors and tissue organization can be controlled by membrane geometry, and cell-dense thick tissues can be reconstructed by layering cells cultured on biodegradable microporous membranes. Applications extend from liver parenchymal cell monoculture to multi-cell type cultures for the reconstruction of 3D functional liver tissue. This review focuses on the expanding role for microporous membranes in liver tissue engineering, primarily from our research.

本文言語English
ページ(範囲)290-295
ページ数6
ジャーナルBiomatter
2
4
出版ステータスPublished - 2012 10月
外部発表はい

ASJC Scopus subject areas

  • 生体医工学
  • 生体材料
  • 医学(その他)

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