抄録
Skeletal muscle is the dominant organ in locomotion and energy metabolism so that maintaining skeletal muscle function is a prerequisite for our health and independent living throughout the life. A loss or decrease in skeletal muscle function leads to increased morbid-ity and mortality through the development of secondary diseases such as metabolic syndrome, type 2 diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The recent discov-ery of microRNAs (miRNAs) provides a new knowledge controlling skeletal muscle function. miRNAs suppress gene expression through either in inhibition of protein translation or in deg-radation of the mRNA transcripts through a process similar to RNA interference (RNAi). This review provides the current understanding in skeletal muscle miRNA biology and focuses on their role and regulation under physiological conditions with exercise.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 61-70 |
| ページ数 | 10 |
| ジャーナル | Japanese Journal of Physical Fitness and Sports Medicine |
| 巻 | 61 |
| 発行部数 | 1 |
| 出版物ステータス | Published - 2012 2 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
これを引用
MicroRNAs in skeletal muscle. / Akimoto, Takayuki; Sawada, Shuji.
：: Japanese Journal of Physical Fitness and Sports Medicine, 巻 61, 番号 1, 02.2012, p. 61-70.研究成果: Review article
}
TY - JOUR
T1 - MicroRNAs in skeletal muscle
AU - Akimoto, Takayuki
AU - Sawada, Shuji
PY - 2012/2
Y1 - 2012/2
N2 - Skeletal muscle is the dominant organ in locomotion and energy metabolism so that maintaining skeletal muscle function is a prerequisite for our health and independent living throughout the life. A loss or decrease in skeletal muscle function leads to increased morbid-ity and mortality through the development of secondary diseases such as metabolic syndrome, type 2 diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The recent discov-ery of microRNAs (miRNAs) provides a new knowledge controlling skeletal muscle function. miRNAs suppress gene expression through either in inhibition of protein translation or in deg-radation of the mRNA transcripts through a process similar to RNA interference (RNAi). This review provides the current understanding in skeletal muscle miRNA biology and focuses on their role and regulation under physiological conditions with exercise.
AB - Skeletal muscle is the dominant organ in locomotion and energy metabolism so that maintaining skeletal muscle function is a prerequisite for our health and independent living throughout the life. A loss or decrease in skeletal muscle function leads to increased morbid-ity and mortality through the development of secondary diseases such as metabolic syndrome, type 2 diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The recent discov-ery of microRNAs (miRNAs) provides a new knowledge controlling skeletal muscle function. miRNAs suppress gene expression through either in inhibition of protein translation or in deg-radation of the mRNA transcripts through a process similar to RNA interference (RNAi). This review provides the current understanding in skeletal muscle miRNA biology and focuses on their role and regulation under physiological conditions with exercise.
KW - Exercise
KW - Training
KW - Transcription
KW - Translation
UR - http://www.scopus.com/inward/record.url?scp=84861367196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861367196&partnerID=8YFLogxK
M3 - Review article
VL - 61
SP - 61
EP - 70
JO - Japanese Journal of Physical Fitness and Sports Medicine
JF - Japanese Journal of Physical Fitness and Sports Medicine
SN - 0039-906X
IS - 1
ER -