抄録
Skeletal muscle is the dominant organ in locomotion and energy metabolism so that maintaining skeletal muscle function is a prerequisite for our health and independent living throughout the life. A loss or decrease in skeletal muscle function leads to increased morbid-ity and mortality through the development of secondary diseases such as metabolic syndrome, type 2 diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The recent discov-ery of microRNAs (miRNAs) provides a new knowledge controlling skeletal muscle function. miRNAs suppress gene expression through either in inhibition of protein translation or in deg-radation of the mRNA transcripts through a process similar to RNA interference (RNAi). This review provides the current understanding in skeletal muscle miRNA biology and focuses on their role and regulation under physiological conditions with exercise.
本文言語 | English |
---|---|
ページ(範囲) | 61-70 |
ページ数 | 10 |
ジャーナル | japanese journal of physical fitness and sports medicine |
巻 | 61 |
号 | 1 |
DOI | |
出版ステータス | Published - 2012 2月 |
外部発表 | はい |
ASJC Scopus subject areas
- 整形外科およびスポーツ医学
- 理学療法、スポーツ療法とリハビリテーション