Mitochondrial macrohaplogroup associated with muscle power in healthy adults

N. Fuku*, H. Murakami, M. Iemitsu, K. Sanada, M. Tanaka, M. Miyachi

*この研究の対応する著者

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The present study was undertaken to examine the effect of mitochondrial haplogroups on aerobic and anaerobic performance phenotypes such as maximum oxygen consumption, muscle power, and muscle mass. We recruited 474 healthy Japanese individuals and measured their physical performance phenotypes such as peak oxygen uptake, muscle power, and muscle mass. The genotypes for 186 polymorphisms in the mitochondrial DNA were determined, and the haplotypes were classified into 2 macrohaplogroups (i. e., N and M) and 12 haplogroups (i. e., F, B, A, N9a, N9b, M7a, M7b, G1, G2, D4a, D4b, and D5). When we compared the 2 major Japanese macrohaplogroups, leg extension power (P=0.0395), leg extension power based on body weight (P=0.0343), and vertical jump performance (P=0.0485) were significantly higher in subjects with mitochondrial macrohaplogroup N than in those with macrohaplogroup M. However, peak oxygen uptake was similar between the 2 groups. When we analyzed the 12 haplogroups, all of the measured parameters were similar among them. In conclusion, mitochondrial macrohaplogroup N may be one of the determinant factors of anaerobic physical performance phenotype such as muscle power.

本文言語English
ページ(範囲)410-414
ページ数5
ジャーナルInternational journal of sports medicine
33
5
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 理学療法、スポーツ療法とリハビリテーション

フィンガープリント

「Mitochondrial macrohaplogroup associated with muscle power in healthy adults」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル