Modality-specific impairment of hippocampal CA1 neurons of alzheimer's disease model mice

Risa Takamura, Kotaro Mizuta, Yukiko Sekine, Tanvir Islam, Takashi Saito, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Toshio Ohshima, Takaomi C. Saido, Yasunori Hayashi*

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Impairment of episodic memory, a class of memory for spatiotemporal context of an event, is an early symptom of Alzheimer's disease. Both spatial and temporal information are encoded and represented in the hippocampal neurons, but how these representations are impaired under amyloid β (Aβ) pathology remains elusive. We performed chronic imaging of the hippocampus in awake male amyloid precursor protein (App) knock-in mice behaving in a virtual reality environment to simultaneously monitor spatiotemporal representations and the progression of Aβ depositions. We found that temporal representation is preserved, whereas spatial representation is significantly impaired in the App knock-in mice. This is because of the overall reduction of active place cells, but not time cells, and compensatory hyperactivation of remaining place cells near Aβ aggregates. These results indicate the differential impact of Aβ aggregates on two major modalities of episodic memory, suggesting different mechanisms for forming and maintaining these two representations in the hippocampus.

本文言語English
ページ(範囲)5315-5329
ページ数15
ジャーナルJournal of Neuroscience
41
24
DOI
出版ステータスPublished - 2021 6 16

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Modality-specific impairment of hippocampal CA1 neurons of alzheimer's disease model mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル