Modeling of signal transmissions in nerves in vitro for the development of a renal nerve cooling device for hypertension control

Takuya Ito, H. Miura, T. Shiga, M. O. Hashem, K. Kamiya, A. Yamada, Y. Tsuboko, K. Sano, Y. Taira, Y. Shiraishi, H. Kumagai, T. Yambe

研究成果: Conference contribution

抄録

Hyperactivity of the central nervous system may increase feedback gains in the hemodynamic system. We have been developing a totally implantable renal nerve cooling system which is capable of changing the hyperactive renal nerve function; in particular, those that reversibly eliminate excess signal-gains by using Peltier effects. In this study, we examined the effect of cooling on neurotransmission in vivo and in vitro. Then we evaluated functional characteristics of signal transmission by the change in thermal implication on the nerve to perform thermal sedation of nervous activity. After the animal experimental procedures, we examined the electrical signal transmission in the nerves extracted from the goats. Using the neurogram amplifier and the functional signal generator, we tested the signal transmission characteristics through the nerves and evaluated their filtering functions by regional nerve cooling. In order to examine of natural renal neurotransmission, the renal nerves were dissected from the left kidney in goats under the normal anesthesia using 2.5% of isoflurane. Aortic pressure and the neurogram were measured, and we applied the low-temperature exposure of the nerve. The electric signals exhibited filtered-transmission through the nerve by the cooling in vitro. In the goat’s experiment, the amplitude of the signal which was obtained at the renal nerve decreased when we decreased the nerve surface temperature by -15 degrees. Then we could evaluate these transmission functions of the renal nerve with the interactive changes of the temperature which was to be controlled by the cooling device. We examined characteristics of the signal transmission in the renal nerve in goats by cooling. And we could evaluate these changes in the functional transmission model with the thermal interactions.

本文言語English
ホスト出版物のタイトルThe 15th International Conference on Biomedical Engineering, ICBME 2013
編集者James Goh
出版社Springer Verlag
ページ448-451
ページ数4
ISBN(電子版)9783319029122
DOI
出版ステータスPublished - 2014
外部発表はい
イベント15th International Conference on Biomedical Engineering, ICBME 2013 - Singapore, Singapore
継続期間: 2013 12 42013 12 7

出版物シリーズ

名前IFMBE Proceedings
43
ISSN(印刷版)1680-0737

Other

Other15th International Conference on Biomedical Engineering, ICBME 2013
CountrySingapore
CitySingapore
Period13/12/413/12/7

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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