Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids

S. Kikuchi*, T. Sakamoto, C. Ishikawa, Kazunaga Yazawa, S. Torii

*この研究の対応する著者

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Eosinophil accumulation induced by leukotriene B4 appears to be involved in the pathogenesis of allergic diseases. We evaluated the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on chemotaxis to leukotriene B4 in guinea pig peritoneal eosinophils. Guinea pigs that were sensitized to polymyxin B were administered an intraperitoneal injection of polymyxin B (1 mg/animal) alone or combined with DHA (15 or 50 mg/kg, i.p.), EPA (50 or 100 mg/kg, i.p.), or with linoleic acid (LA) (100 mg/kg, i.p.). Forty hours later, eosinophils were obtained from the intraperitoneal ravage fluid and purified. The chemotactic and chemokinetic responses of eosinophils to leukotriene 3, were measured using a 96-well microchemotaxis chamber. DHA significantly decreased the chemotactic and chemokinetic responses of eosinophils in a dose-dependent fashion. A higher dose of EPA also significantly inhibited both of those responses, whereas LA had no effect. Our results suggested a possible mechanism for the improvement of allergic diseases by dietary supplementation with n-3 PUFA.

本文言語English
ページ(範囲)243-248
ページ数6
ジャーナルProstaglandins Leukotrienes and Essential Fatty Acids
58
3
DOI
出版ステータスPublished - 1998 3月
外部発表はい

ASJC Scopus subject areas

  • 臨床生化学
  • 内分泌学、糖尿病および代謝内科学

フィンガープリント

「Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル