Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome Critical Region gene 5)

Dong Kug Choi, Yutaka Suzuki, Shinichiro Yoshimura, Takushi Togashi, Munetomo Hida, Todd D. Taylor, Yuepeng Wang, Sumio Sugano, Masahira Hattori, Yoshiyuki Sakaki

研究成果: Article

4 引用 (Scopus)

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For understanding the pathogenesis of Down syndrome (DS), it is important to identify and characterize the genes on Chromosome (Chr) 21, especially those in the Down syndrome critical region (DSCR) on Chr 21q22.2. Recently we have determined 33.5 Mb (more than 99%) of DNA sequence of Chr 21 and, from these sequence data, we identified a novel gene, DSCR5 (transcript = 0.8 kb), from DSCR by combination of computational gene prediction and cDNA screening. For functional analysis of DSCR5, we identified a mouse homolog of the DSCR5 cDNA, and termed it mDscr5 (transcript length = 0.8 kb). The gene was mapped to mouse Chr 16 C3-C4, the syntenic region of human Chr 21, and encodes an amino acid of 132 residues with 90% identity to DSCR5. In situ hybridization showed that mDscr5 is predominantly expressed in the developing tongue. To our best knowledge, no other gene in DSCR is reported to be expressed in tongue, so that DSCR5 may be the first candidate to elucidate the pathophysiology of tongue malformation observed in DS.

元の言語English
ページ(範囲)347-351
ページ数5
ジャーナルMammalian Genome
12
発行部数5
DOI
出版物ステータスPublished - 2001
外部発表Yes

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ASJC Scopus subject areas

  • Genetics

これを引用

Choi, D. K., Suzuki, Y., Yoshimura, S., Togashi, T., Hida, M., Taylor, T. D., Wang, Y., Sugano, S., Hattori, M., & Sakaki, Y. (2001). Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome Critical Region gene 5). Mammalian Genome, 12(5), 347-351. https://doi.org/10.1007/s003350010283