Molecular cloning and chromosomal localization of the human thrombopoietin gene Yoshiaki Sohma a, Hiromichi Akahori a, Naohiko Seki b,c, Tada-aki Hori b, Kinya Ogami a

研究成果: Article査読

抄録

The complete gene for human thrombopoietin (TPO) has been cloned by screening a human genomic library using human TPO cDNA as a probe. This gene is 6.2 kb in length and contains six exons and five introns. It is shown that the human genome contains a single copy of the human TPO gene according to Southern blotting analysis. The transcription initiation site was determined by SI nuclease mapping. The human TPO gene expressed TPO activity when transfected into COS-1 cells. The human TPO gene has been mapped to chromosome 3q27 by in situ hybridization using a biotin-labeled probe.

本文言語English
ページ(範囲)57-61
ページ数5
ジャーナルFEBS Letters
353
1
出版ステータスPublished - 1994 1 1
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

フィンガープリント 「Molecular cloning and chromosomal localization of the human thrombopoietin gene Yoshiaki Sohma a, Hiromichi Akahori a, Naohiko Seki b,c, Tada-aki Hori b, Kinya Ogami a」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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