Molecular design and morphology of peptide nanotubes: Towards the novel drug delivery materials

H. Okamoto, K. Takeda

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Peptide nanotubes (PNTs) are an artificial protein, being formed by the self-assembly of peptide nanorings (PNRs) consisting of alternate sequences of D- and L-amino acid residues (D,L-peptide). Because they have hollow cores and internal cavities, they are expected to be the novel drug delivery system in the future. Here, in order to give the guiding principle of the molecular design, possible molecular conformations of the peptide nanorings and nanotubes were theoretically investigated and the electronic structures were also studied by ab initio calculations. The syntheses and atomic force microscopy were further performed and the morphology of the peptide nanotubes was investigated experimentally.

本文言語English
ページ(範囲)97-107
ページ数11
ジャーナルJournal of Drug Delivery Science and Technology
15
1
DOI
出版ステータスPublished - 2005

ASJC Scopus subject areas

  • Pharmaceutical Science

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