Molecular design of artificial hydrolytic nucleases and ribonucleases.

M. Komiyama*, T. Inokawa, T. Shiiba, N. Takeda, K. Yoshinari, M. Yashiro

*この研究の対応する著者

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63. Site-selective hydrolysis of DNAs has been accomplished by the lanthanide complexes bound to DNA oligomers. No concurrent oxidative cleavage of the ribose or the deoxyribose takes place.

本文言語English
ページ(範囲)197-198
ページ数2
ジャーナルNucleic acids symposium series
29
出版ステータスPublished - 1993
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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