抄録
Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63. Site-selective hydrolysis of DNAs has been accomplished by the lanthanide complexes bound to DNA oligomers. No concurrent oxidative cleavage of the ribose or the deoxyribose takes place.
本文言語 | English |
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ページ(範囲) | 197-198 |
ページ数 | 2 |
ジャーナル | Nucleic acids symposium series |
号 | 29 |
出版ステータス | Published - 1993 |
外部発表 | はい |
ASJC Scopus subject areas
- 医学(全般)