Molecular design of biodegradable polymeric micelles for temperature-responsive drug release

Masamichi Nakayama, Teruo Okano*, Takanari Miyazaki, Fukashi Kohori, Kiyotaka Sakai, Masayuki Yokoyama

*この研究の対応する著者

研究成果: Article査読

294 被引用数 (Scopus)

抄録

We designed thermo-responsive and biodegradable polymeric micelles for an ideal drug delivery system whose target sites are where external stimuli selectively release drugs from the polymeric micelles. The thermo-responsive micelles formed from block copolymers that were composed both of a hydrophobic block and a thermo-responsive block. Poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) showing a lower critical solution temperature (LCST) around 40 °C was synthesized for the thermo-responsive block, while biodegradable poly(d,l-lactide), poly(ε-caprolactone), or poly(d,l-lactide-co-ε-caprolactone) was used for the hydrophobic block. By changing both the block lengths of the poly(d,l-lactide)-containing block copolymers, physical parameters such as micelle diameter and critical micelle concentration were varied. On the other hand, the choice of the hydrophobic block was revealed to be critical in relation to both on the thermo-responsive release of the incorporated anti-cancer drug, doxorubicin, and the temperature-dependent change of the hydrophobicity of the micelles' inner core. One polymeric micelle composition successfully exhibited rapid and thermo-responsive drug release while possessing a biodegradable character.

本文言語English
ページ(範囲)46-56
ページ数11
ジャーナルJournal of Controlled Release
115
1
DOI
出版ステータスPublished - 2006 9 28

ASJC Scopus subject areas

  • 薬科学

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